top space
bottom spacer
Home > Our Products > Prelude SkinPrep System

Prelude SkinPrep System


Echo is developing its Prelude® SkinPrep System as an effective, easy-to-use transdermal skin permeation device for our Symphony® CGM System to affect the flow of interstitial fluids and molecules across the stratum corneum, the outmost protective layer of the skin. Prelude incorporates our patented skin permeation control technology into a comfortable, hand-held device used to prepare a small area of the skin for the non-invasive sensor components of our CGM system. We have successfully used Prelude to increase the permeability of the skin allowing for analyte extraction and drug delivery in both internal and external clinical trials.

The key feature of our skin permeation technology is our patented feedback control algorithm to achieve optimal and pain-free skin preparation for our transdermal sensing technologies. While the system is in operation, the Prelude SkinPrep System measures the real-time electrical conductivity of the test skin site. The system turns off automatically when the conductivity measurement reaches the appropriate level as identified by the algorithm, thus producing individualized, optimal skin permeation. As a result, the system only removes the outmost layer of the epidermis, the stratum corneum, a layer of about 0.01 mm in thickness consisting of only dry, dead skin cells. With the advantages of our proprietary feedback control algorithm, we believe the skin permeation process is safe, effective, fast-acting and painless.